› 5f18

X-ray diffraction
2Å resolution

Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1

Released:
DOI: 10.2210/pdb5f18/pdb
PDB entry 5f18 coloured by chain, front view.
PDB entry 5f18 coloured by chain, side view.
PDB entry 5f18 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.
Wang H, Shi Y, Song J, Qi J, Lu G, Yan J, Gao GF
Cell 164 258-268 (2016)
PMID: 26771495

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127297 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NPC intracellular cholesterol transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15118 (Residues: 374-620; Coverage: 20%)
Gene name: NPC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P6122
Unit cell:
a: 60.006Å b: 60.006Å c: 270.347Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.219
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Fusion of Enveloped Viruses in Endosomes.
White et al. (2016)
29 more

3 mentions without citation

Functional Characterization of Adaptive Mutations during the West African Ebola Virus Outbreak.
Dietzel et al. (2017)
2 more