› 5f71

X-ray diffraction
2.4Å resolution

Human T-cell immunoglobulin and mucin domain protein 3 (hTIM-3)

Released:
DOI: 10.2210/pdb5f71/pdb
PDB entry 5f71 coloured by chain, front view.
PDB entry 5f71 coloured by chain, side view.
PDB entry 5f71 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors
Wang H, Qi JX, Liu NN
Chin. Sci. Bull. 60 3438-3453 (2015)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatitis A virus cellular receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TDQ0 (Residues: 22-130; Coverage: 39%)
Gene names: HAVCR2, TIM3, TIMD3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 53.997Å b: 61.957Å c: 67.152Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.257
Expression system: Escherichia coli

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