› 5fb8

X-ray diffraction
2.07Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212015 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Anti-IL-16 antibody 14.1 Fab domain Kappa Chain Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 23.82 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Anti-IL-16 antibody 14.1 Fab domain Heavy Chain Chain: B
Molecule details ›
Chain: B
Length: 224 amino acids
Theoretical weight: 24.18 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Interleukin-16 Chain: C
Molecule details ›
Chain: C
Length: 102 amino acids
Theoretical weight: 10.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14005 (Residues: 1224-1323; Coverage: 8%)
Gene name: IL16
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand EDO 7 x EDO
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 59.69Å b: 65.95Å c: 196.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.205
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Mast Cell Cytokines in Acute and Chronic Gingival Tissue Inflammation: Role of IL-33 and IL-37.
Trimarchi et al. (2022)
3 other articles

2 mentions without citation

An epitope-enriched immunogen expands responses to a conserved viral site.
Caradonna et al. (2022)
1 more