› 5fbn

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chains: C, D
Molecule details ›
Chains: C, D
Length: 271 amino acids
Theoretical weight: 31.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 389-659; Coverage: 41%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 5WF 2 x 5WF
Ligand 5WE 4 x 5WE
Ligand CL 2 x CL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 38.262Å b: 71.475Å c: 103.056Å
α: 90° β: 90.68° γ: 90°
R-values:
R R work R free
0.182 0.179 0.226
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Investigational Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis.
Norman P. (2016)
2 more

9 mentions without citation

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.
Leach et al. (2020)
8 more