› 5fdy

X-ray diffraction
1.85Å resolution

Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain, C72A/C75A mutant

Released:
DOI: 10.2210/pdb5fdy/pdb
PDB entry 5fdy coloured by chain, front view.
PDB entry 5fdy coloured by chain, side view.
PDB entry 5fdy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binary architecture of the Nav1.2-β2 signaling complex.
Das S, Gilchrist J, Bosmans F, Van Petegem F
Elife 5 (2016)
PMID: 26894959

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel subunit beta-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60939 (Residues: 30-153; Coverage: 67%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 28.386Å b: 36.18Å c: 59.186Å
α: 89.96° β: 89.99° γ: 76.36°
R-values:
R R work R free
0.158 0.156 0.185
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease.
Hull et al. (2018)
4 more

3 mentions without citation

Sixty-five years of the long march in protein secondary structure prediction: the final stretch?
Yang et al. (2018)
2 more