› 5fm9

X-ray diffraction
2.92Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurogenic locus notch homolog protein 1 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 16.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P46531 (Residues: 140-294; Coverage: 6%)
Gene names: NOTCH1, TAN1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 142.26Å b: 21.15Å c: 83.56Å
α: 90° β: 116.27° γ: 90°
R-values:
R R work R free
0.214 0.212 0.237
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
Kovall et al. (2017)
4 more

3 mentions without citation

The biology of SCUBE.
Lin et al. (2023)
2 more