› 5fmw

Electron Microscopy
6.7Å resolution

The poly-C9 component of the Complement Membrane Attack Complex

Released:
DOI: 10.2210/pdb5fmw/pdb
PDB entry 5fmw coloured by chain, front view.
PDB entry 5fmw coloured by chain, side view.
PDB entry 5fmw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the poly-C9 component of the complement membrane attack complex.
Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RH, Ekkel SM, Kondos SC, Goode RJ, Ramm G, Whisstock JC, Saibil HR, Dunstone MA
Nat Commun 7 10588 (2016)
PMID: 26841934
Related structures: EMD-3235

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 22-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement component C9 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V
Length: 506 amino acids
Theoretical weight: 57.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02748 (Residues: 39-544; Coverage: 94%)
Gene name: C9
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.7Å
Relevant EMDB volumes: EMD-3235

Quick links

Citations

24 review citations

The "ins and outs" of complement-driven immune responses.
Freeley et al. (2016)
23 more

4 mentions without citation

The mystery behind membrane insertion: a review of the complement membrane attack complex.
Bayly-Jones et al. (2017)
3 more