› 5for

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoinositide 3-kinase adapter protein 1 Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 16.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6ZUJ8 (Residues: 7-142; Coverage: 17%)
Gene names: BCAP, PIK3AP1
Sequence domains: Toll/interleukin-1 receptor domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

2 bound ligands:
Ligand 1PE 1 x 1PE
Ligand I3C 1 x I3C
1 modified residue:
Ligand MLY 3 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6222
Unit cell:
a: 135.042Å b: 135.042Å c: 42.912Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.188 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Regulation and repurposing of nutrient sensing and autophagy in innate immunity.
Sanchez-Garrido et al. (2021)
5 more

1 mention without citation

Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome.
Halabi et al. (2017)