› 5fv1

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210649 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
VK DOMAIN ANTIBODY Chains: L, M
Molecule details ›
Chains: L, M
Length: 108 amino acids
Theoretical weight: 12.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
N-VEGF Chains: V, W
Molecule details ›
Chains: V, W
Length: 116 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 207-316; Coverage: 28%)
Gene names: VEGF, VEGFA
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND
Spacegroup: I222
Unit cell:
a: 61.221Å b: 147.128Å c: 175.171Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.261
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers.
Arezumand et al. (2017)
1 more

5 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
4 more