› 5fv2

X-ray diffraction
3.45Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210650 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
VH DOMAIN ANTIBODY Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 116 amino acids
Theoretical weight: 12.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
N-VEGF Chains: V, W, X
Molecule details ›
Chains: V, W, X
Length: 116 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15692 (Residues: 207-316; Coverage: 28%)
Gene names: VEGF, VEGFA
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: C2
Unit cell:
a: 107.108Å b: 130.397Å c: 81.178Å
α: 90° β: 106.53° γ: 90°
R-values:
R R work R free
0.215 0.212 0.263
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers.
Arezumand et al. (2017)
1 more

4 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
3 more