› 5fxs

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08069 (Residues: 980-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ACT 3 x ACT
Ligand OZN 1 x OZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P212121
Unit cell:
a: 40.82Å b: 66.11Å c: 122.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.214
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Standing on the shoulders of giants: a retrospective analysis of kinase drug discovery at AstraZeneca.
Kettle et al. (2016)
5 other articles

5 mentions without citation

Transformer neural network for protein-specific de novo drug generation as a machine translation problem.
Grechishnikova D. (2021)
4 more