› 5gge

X-ray diffraction
1.86Å resolution

Fatty Acid-Binding Protein in Brain Tissue of Drosophila melanogaster

Released:
DOI: 10.2210/pdb5gge/pdb
PDB entry 5gge coloured by chain, front view.
PDB entry 5gge coloured by chain, side view.
PDB entry 5gge coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport.
Cheng YY, Huang YF, Lin HH, Chang WW, Lyu PC
Biochim Biophys Acta Mol Cell Biol Lipids 1864 158506 (2019)
PMID: 31404652

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic fatty-acid binding proteins domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.52 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9VGM2 (Residues: 1-130; Coverage: 100%)
Gene names: BcDNA:RH06221, BcDNA:RH46282, BcDNA:RH49003, BcDNA:SD12036, CG31305, CG31305-PI, CG6783, CT21061, Dmel\CG6783, Dmel_CG6783, FABP, anon-EST:Posey234, anon-WO0140519.12, dFabp, fabp
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: I422
Unit cell:
a: 61.698Å b: 61.698Å c: 137.321Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.179 0.246
Expression system: Escherichia coli BL21

Quick links

Citations

4 citation in other articles

Two fatty acid-binding proteins expressed in the intestine interact differently with endocannabinoids.
Lai et al. (2020)
3 more