› 5git

X-ray diffraction
2.19Å resolution

BTB domain of KEAP1 in complex with XX3

Released:
DOI: 10.2210/pdb5git/pdb
PDB entry 5git coloured by chain, front view.
PDB entry 5git coloured by chain, side view.
PDB entry 5git coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Wu G, Zhu L, Yuan X, Chen H, Xiong R, Zhang S, Cheng H, Shen Y, An H, Li T, Li H, Zhang W
Antioxid Redox Signal 27 754-768 (2017)
PMID: 28186440

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171933 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 48-180; Coverage: 21%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: BTB/POZ domain

Ligands and Environments

1 bound ligand:
Ligand XXT 1 x XXT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P6522
Unit cell:
a: 42.45Å b: 42.45Å c: 265.15Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.216 0.278
Expression system: Escherichia coli

Quick links

Citations

14 review citations

P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease.
Sita et al. (2017)
13 more

2 mentions without citation

Anticancer Targets and Signaling Pathways Activated by Britannin and Related Pseudoguaianolide Sesquiterpene Lactones.
Bailly C. (2021)
1 more