› 5glj

X-ray diffraction
1.6Å resolution

Crystal Structure of PDZ1 Domain of Human Protein Tyrosine Phosphatase PTP-Bas

Released:
DOI: 10.2210/pdb5glj/pdb
PDB entry 5glj coloured by chain, front view.
PDB entry 5glj coloured by chain, side view.
PDB entry 5glj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas.
Lee SO, Lee MK, Ku B, Bae KH, Lee SC, Lim HM, Kim SJ, Chi SW
Biochem Biophys Res Commun 478 1205-10 (2016)
PMID: 27544031

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 13 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 96 amino acids
Theoretical weight: 10.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12923 (Residues: 1086-1178; Coverage: 4%)
Gene names: PNP1, PTP1E, PTPL1, PTPN13
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P212121
Unit cell:
a: 32.034Å b: 57.571Å c: 168.971Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.206
Expression system: Escherichia coli

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