5gn0

X-ray diffraction
2.9Å resolution

Structure of TAZ-TEAD complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-178932 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 225 amino acids
Theoretical weight: 26.42 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62296 (Residues: 210-427; Coverage: 51%)
Gene names: Tcf13r1, Tead4, Tef3, Tefr1
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1
WW domain-containing transcription regulator protein 1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 35 amino acids
Theoretical weight: 4.08 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9EPK5 (Residues: 24-57; Coverage: 9%)
Gene names: Taz, Wwtr1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 79.66Å b: 120.9Å c: 196.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.26
Expression system: Escherichia coli