› 5gnh

X-ray diffraction
2.6Å resolution

Myotubularin-related protein 2

Released:
DOI: 10.2210/pdb5gnh/pdb
PDB entry 5gnh coloured by chain, front view.
PDB entry 5gnh coloured by chain, side view.
PDB entry 5gnh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lee BI, Bong SM

Function and Biology Details

Reactions catalysed: 
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171777 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myotubularin-related protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 571 amino acids
Theoretical weight: 66.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13614 (Residues: 73-643; Coverage: 89%)
Gene names: KIAA1073, MTMR2
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: C2
Unit cell:
a: 158.344Å b: 82.82Å c: 99.972Å
α: 90° β: 117.59° γ: 90°
R-values:
R R work R free
0.206 0.203 0.258
Expression system: Escherichia coli

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