› 5gup

Electron Microscopy
4Å resolution

Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1

Released:
DOI: 10.2210/pdb5gup/pdb
PDB entry 5gup coloured by chain, front view.
PDB entry 5gup coloured by chain, side view.
PDB entry 5gup coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structure of Mammalian Respiratory Supercomplex I1III2IV1.
Wu M, Gu J, Guo R, Huang Y, Yang M
Cell 167 1598-1609.e10 (2016)
PMID: 27912063
Related structures: EMD-9539

Function and Biology Details

Reaction catalysed: 
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 80-mer (preferred)
PDBe Complex ID:
PDB-CPX-236795 (preferred)
Entry contents:
67 distinct polypeptide molecules
Macromolecules (67 distinct):
Cytochrome c oxidase subunit 6C Chain: A
Molecule details ›
Chain: A
Length: 73 amino acids
Theoretical weight: 8.49 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 464 amino acids
Theoretical weight: 50.64 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SZP7 (Residues: 1-464; Coverage: 100%)
Gene name: NDUFV1
Sequence domains:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Chain: C
Molecule details ›
Chain: C
Length: 463 amino acids
Theoretical weight: 52.55 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S1A8 (Residues: 7-469; Coverage: 100%)
Gene name: NDUFS2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chain: D
Molecule details ›
Chain: D
Length: 264 amino acids
Theoretical weight: 30.24 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Chain: E
Molecule details ›
Chain: E
Length: 249 amino acids
Theoretical weight: 26.3 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SM98 (Residues: 30-231; Coverage: 87%)
Gene name: NDUFV2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chain: F
Molecule details ›
Chain: F
Length: 123 amino acids
Theoretical weight: 13.35 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S031 (Residues: 1-123; Coverage: 100%)
Gene name: NDUFS6
Sequence domains: Zinc-finger domain
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chain: G
Molecule details ›
Chain: G
Length: 727 amino acids
Theoretical weight: 79.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1V1H9 (Residues: 1-727; Coverage: 100%)
Gene name: NDUFS1
Sequence domains:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Chain: H
Molecule details ›
Chain: H
Length: 212 amino acids
Theoretical weight: 23.89 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Chain: I
Molecule details ›
Chain: I
Length: 216 amino acids
Theoretical weight: 23.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1TL60 (Residues: 1-21, 22-196; Coverage: 100%)
Gene name: NDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: J
Molecule details ›
Chain: J
Length: 175 amino acids
Theoretical weight: 19.72 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: G8IFA6 (Residues: 1-175; Coverage: 100%)
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chains: K, R
Molecule details ›
Chains: K, R
Length: 145 amino acids
Theoretical weight: 17.16 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SQP4 (Residues: 1-145; Coverage: 100%)
Gene name: NDUFA12
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chain: L
Molecule details ›
Chain: L
Length: 377 amino acids
Theoretical weight: 42.61 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SL07 (Residues: 10-372; Coverage: 100%)
Gene name: NDUFA9
Sequence domains: NAD dependent epimerase/dehydratase family
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chain: M
Molecule details ›
Chain: M
Length: 113 amino acids
Theoretical weight: 12.65 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Chain: N
Molecule details ›
Chain: N
Length: 116 amino acids
Theoretical weight: 13.32 KDa
Source organism: Sus scrofa
Acyl carrier protein, mitochondrial Chains: O, X
Molecule details ›
Chains: O, X
Length: 156 amino acids
Theoretical weight: 17.33 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Chain: P
Molecule details ›
Chain: P
Length: 99 amino acids
Theoretical weight: 11.1 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RGE3 (Residues: 1-99; Coverage: 100%)
Gene name: NDUFA2
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chain: Q
Molecule details ›
Chain: Q
Length: 128 amino acids
Theoretical weight: 14.95 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: S
Molecule details ›
Chain: S
Length: 70 amino acids
Theoretical weight: 8.09 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GR43 (Residues: 1-70; Coverage: 100%)
Gene name: NDUFA1
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chain: T
Molecule details ›
Chain: T
Length: 84 amino acids
Theoretical weight: 9.23 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VPG4 (Residues: 86-169; Coverage: 50%)
Gene name: NDUFA3
Sequence domains: NADH dehydrogenase 1 alpha subcomplex subunit 3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chain: U
Molecule details ›
Chain: U
Length: 357 amino acids
Theoretical weight: 40.48 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SIS9 (Residues: 1-357; Coverage: 100%)
Gene name: NDUFA10
Sequence domains: Deoxynucleoside kinase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chain: V
Molecule details ›
Chain: V
Length: 141 amino acids
Theoretical weight: 14.69 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LGM4 (Residues: 1-141; Coverage: 100%)
Gene name: NDUFA11
Sequence domains: Tim17/Tim22/Tim23/Pmp24 family
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: W
Molecule details ›
Chain: W
Length: 144 amino acids
Theoretical weight: 16.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1NRT6 (Residues: 1-144; Coverage: 100%)
Gene name: NDUFA13
Sequence domains: GRIM-19 protein
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Chain: Y
Molecule details ›
Chain: Y
Length: 105 amino acids
Theoretical weight: 11.94 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chain: Z
Molecule details ›
Chain: Z
Length: 98 amino acids
Theoretical weight: 11.13 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VBN1 (Residues: 17-114; Coverage: 86%)
Gene name: NDUFB3
Sequence domains: NADH-ubiquinone oxidoreductase B12 subunit family
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chain: a
Molecule details ›
Chain: a
Length: 189 amino acids
Theoretical weight: 21.59 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SGC6 (Residues: 1-189; Coverage: 100%)
Gene name: NDUFB5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Chain: b
Molecule details ›
Chain: b
Length: 128 amino acids
Theoretical weight: 15.6 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q2EN80 (Residues: 1-128; Coverage: 100%)
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chain: c
Molecule details ›
Chain: c
Length: 186 amino acids
Theoretical weight: 21.7 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RWL7 (Residues: 1-186; Coverage: 100%)
Gene name: NDUFB8
Sequence domains: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chain: d
Molecule details ›
Chain: d
Length: 176 amino acids
Theoretical weight: 20.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LDC3 (Residues: 1-201; Coverage: 88%)
Gene name: NDUFB10
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chain: e
Molecule details ›
Chain: e
Length: 154 amino acids
Theoretical weight: 17.38 KDa
Source organism: Sus scrofa
Protein MGARP N-terminal domain-containing protein Chain: f
Molecule details ›
Chain: f
Length: 76 amino acids
Theoretical weight: 8.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RRC9 (Residues: 1-7, 8-16, 17-55; Coverage: 25%)
Gene name: MGARP
Sequence domains: Mitochondria Localisation Sequence
NADH dehydrogenase [ubiquinone] 1 subunit C2 Chain: g
Molecule details ›
Chain: g
Length: 122 amino acids
Theoretical weight: 14.33 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Chain: h
Molecule details ›
Chain: h
Length: 106 amino acids
Theoretical weight: 12.51 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SV23 (Residues: 1-106; Coverage: 100%)
Gene name: NDUFS5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
NADH-ubiquinone oxidoreductase chain 2 Chain: i
Molecule details ›
Chain: i
Length: 347 amino acids
Theoretical weight: 39.08 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79875 (Residues: 1-347; Coverage: 100%)
Gene names: MT-ND2, MTND2, NADH2, ND2
Sequence domains:
NADH-ubiquinone oxidoreductase chain 3 Chain: j
Molecule details ›
Chain: j
Length: 115 amino acids
Theoretical weight: 13 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79880 (Residues: 1-115; Coverage: 100%)
Gene names: MT-ND3, MTND3, NADH3, ND3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
NADH-ubiquinone oxidoreductase chain 4L Chain: k
Molecule details ›
Chain: k
Length: 98 amino acids
Theoretical weight: 10.83 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P56632 (Residues: 1-98; Coverage: 100%)
Gene names: MT-ND4L, MTND4L, NADH4L, ND4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
NADH-ubiquinone oxidoreductase chain 5 Chain: l
Molecule details ›
Chain: l
Length: 606 amino acids
Theoretical weight: 68.7 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q9TDR1 (Residues: 1-606; Coverage: 100%)
Gene names: MT-ND5, MTND5, NADH5, ND5
Sequence domains:
NADH-ubiquinone oxidoreductase chain 6 Chain: m
Molecule details ›
Chain: m
Length: 175 amino acids
Theoretical weight: 19.02 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79882 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chain: n
Molecule details ›
Chain: n
Length: 58 amino acids
Theoretical weight: 7.04 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D2CGH8 (Residues: 1-58; Coverage: 100%)
Gene name: NDUFB1
Sequence domains: MNLL subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chain: o
Molecule details ›
Chain: o
Length: 129 amino acids
Theoretical weight: 15.12 KDa
Source organism: Sus scrofa
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: p
Molecule details ›
Chain: p
Length: 179 amino acids
Theoretical weight: 21.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GSE5 (Residues: 43-221; Coverage: 81%)
Gene name: NDUFB9
Sequence domains: Complex 1 protein (LYR family)
NADH-ubiquinone oxidoreductase chain 4 Chain: q
Molecule details ›
Chain: q
Length: 459 amino acids
Theoretical weight: 51.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79881 (Residues: 1-459; Coverage: 100%)
Gene names: MT-ND4, MTND4, NADH4, ND4
Sequence domains:
NADH-ubiquinone oxidoreductase chain 1 Chain: r
Molecule details ›
Chain: r
Length: 318 amino acids
Theoretical weight: 35.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79874 (Residues: 1-318; Coverage: 100%)
Gene names: MT-ND1, MTND1, NADH1, ND1
Sequence domains: NADH dehydrogenase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chain: s
Molecule details ›
Chain: s
Length: 172 amino acids
Theoretical weight: 20.06 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SLR1 (Residues: 78-249; Coverage: 69%)
Gene name: NDUFA8
Sequence domains: CHCH domain
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chain: t
Molecule details ›
Chain: t
Length: 137 amino acids
Theoretical weight: 16.49 KDa
Source organism: Sus scrofa
Ubiquinol-cytochrome c reductase core protein 1 Chains: 5, u
Molecule details ›
Chains: 5, u
Length: 480 amino acids
Theoretical weight: 52.76 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SKM0 (Residues: 1-480; Coverage: 100%)
Gene name: UQCRC1
Sequence domains:
Cytochrome b-c1 complex subunit 2, mitochondrial Chains: 6, v
Molecule details ›
Chains: 6, v
Length: 453 amino acids
Theoretical weight: 48.26 KDa
Source organism: Sus scrofa
Cytochrome b Chains: 7, w
Molecule details ›
Chains: 7, w
Length: 379 amino acids
Theoretical weight: 42.84 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q1HBG9 (Residues: 1-379; Coverage: 100%)
Gene names: CYTB, CytB, MT-CYB, cytb
Sequence domains:
Cytochrome c1, heme protein, mitochondrial Chains: 8, x
Molecule details ›
Chains: 8, x
Length: 326 amino acids
Theoretical weight: 35.49 KDa
Source organism: Sus scrofa
Cytochrome b-c1 complex subunit 7 Chains: 9, y
Molecule details ›
Chains: 9, y
Length: 111 amino acids
Theoretical weight: 13.59 KDa
Source organism: Sus scrofa
Cytochrome b-c1 complex subunit 8 Chains: Aa, z
Molecule details ›
Chains: Aa, z
Length: 82 amino acids
Theoretical weight: 9.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1UYT9 (Residues: 1-82; Coverage: 100%)
Gene names: LOC100524308, UQCRQ
Sequence domains: UcrQ family
Cytochrome b-c1 complex subunit 6 Chains: 0, Ab
Molecule details ›
Chains: 0, Ab
Length: 91 amino acids
Theoretical weight: 10.69 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1S3W0 (Residues: 1-91; Coverage: 100%)
Gene names: LOC100524873, UQCRH
Sequence domains: Ubiquinol-cytochrome C reductase hinge protein
Complex III subunit 9 Chains: 1, Ac
Molecule details ›
Chains: 1, Ac
Length: 64 amino acids
Theoretical weight: 7.41 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q2EN79 (Residues: 1-64; Coverage: 100%)
Gene name: UQCR10
Sequence domains: Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Rieske domain-containing protein Chains: 2, 4
Molecule details ›
Chains: 2, 4
Length: 274 amino acids
Theoretical weight: 29.49 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RNZ1 (Residues: 45-51, 52-55, 56-299; Coverage: 85%)
Gene name: UQCRFS1
Sequence domains:
Cytochrome b-c1 complex subunit 10 Chains: 3, Ad
Molecule details ›
Chains: 3, Ad
Length: 56 amino acids
Theoretical weight: 6.56 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SDI2 (Residues: 1-56; Coverage: 100%)
Gene name: UQCR11
Sequence domains: Ubiquinol-cytochrome C reductase complex, 6.4kD protein
Rieske domain-containing protein Chains: Ae, Af
Molecule details ›
Chains: Ae, Af
Length: 78 amino acids
Theoretical weight: 7.9 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RNZ1 (Residues: 45-51, 52-55, 56-103; Coverage: 20%)
Gene name: UQCRFS1
Sequence domains: Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
Cytochrome c oxidase subunit 8B, mitochondrial Chain: Ag
Molecule details ›
Chain: Ag
Length: 46 amino acids
Theoretical weight: 4.97 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 7A1, mitochondrial Chain: Ah
Molecule details ›
Chain: Ah
Length: 59 amino acids
Theoretical weight: 6.68 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 7B, mitochondrial Chain: Ai
Molecule details ›
Chain: Ai
Length: 56 amino acids
Theoretical weight: 6.37 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 7C, mitochondrial Chain: Aj
Molecule details ›
Chain: Aj
Length: 47 amino acids
Theoretical weight: 5.45 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 1 Chain: Ak
Molecule details ›
Chain: Ak
Length: 514 amino acids
Theoretical weight: 57.07 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 2 Chain: Al
Molecule details ›
Chain: Al
Length: 227 amino acids
Theoretical weight: 26.04 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 3 Chain: Am
Molecule details ›
Chain: Am
Length: 261 amino acids
Theoretical weight: 29.94 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chain: An
Molecule details ›
Chain: An
Length: 147 amino acids
Theoretical weight: 17.18 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 5A, mitochondrial Chain: Ao
Molecule details ›
Chain: Ao
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SJ34 (Residues: 44-152; Coverage: 72%)
Gene name: COX5A
Sequence domains: Cytochrome c oxidase subunit Va
Cytochrome c oxidase subunit 5B, mitochondrial Chain: Ap
Molecule details ›
Chain: Ap
Length: 98 amino acids
Theoretical weight: 10.68 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 6A, mitochondrial Chain: Aq
Molecule details ›
Chain: Aq
Length: 84 amino acids
Theoretical weight: 9.45 KDa
Source organism: Sus scrofa
Cytochrome c oxidase subunit 6B1 Chain: Ar
Molecule details ›
Chain: Ar
Length: 85 amino acids
Theoretical weight: 10.04 KDa
Source organism: Sus scrofa

Ligands and Environments

14 bound ligands:
Ligand SF4 6 x SF4
Ligand FMN 1 x FMN
Ligand FES 4 x FES
Ligand PLX 5 x PLX
Ligand NDP 1 x NDP
Ligand ZMP 2 x ZMP
Ligand CDL 10 x CDL
Ligand PEE 10 x PEE
Ligand HEM 4 x HEM
Ligand HEC 2 x HEC
Ligand HEA 2 x HEA
Ligand CU 3 x CU
Ligand MG 1 x MG
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-9539

Quick links

Citations

53 review citations

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain.
Letts et al. (2017)
52 more

18 mentions without citation

Evolution of Structural Biology through the Lens of Mass Spectrometry.
Kaur et al. (2019)
17 more