› 5gwn

X-ray diffraction
1.31Å resolution

Crystal structure of human RCC2

Released:
DOI: 10.2210/pdb5gwn/pdb
PDB entry 5gwn coloured by chain, front view.
PDB entry 5gwn coloured by chain, side view.
PDB entry 5gwn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
RCC2 is a novel p53 target in suppressing metastasis.
Song C, Liang L, Jin Y, Li Y, Liu Y, Guo L, Wu C, Yun CH, Yin Y
Oncogene 37 8-17 (2018)
PMID: 28869598

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192826 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein RCC2 Chain: A
Molecule details ›
Chain: A
Length: 439 amino acids
Theoretical weight: 47.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9P258 (Residues: 89-522; Coverage: 83%)
Gene names: KIAA1470, RCC2, TD60
Sequence domains: Regulator of chromosome condensation (RCC1) repeat

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 94.447Å b: 84.056Å c: 60.671Å
α: 90° β: 101.57° γ: 90°
R-values:
R R work R free
0.172 0.171 0.189
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis.
Kotelevets et al. (2020)
1 more

1 mention without citation

RCC2 is a novel p53 target in suppressing metastasis.
Song et al. (2018)