› 5h08

X-ray diffraction
2.53Å resolution

Human PTPRZ D1 domain complexed with NAZ2329

Released:
DOI: 10.2210/pdb5h08/pdb
PDB entry 5h08 coloured by chain, front view.
PDB entry 5h08 coloured by chain, side view.
PDB entry 5h08 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
Fujikawa A, Sugawara H, Tanaka T, Matsumoto M, Kuboyama K, Suzuki R, Tanga N, Ogata A, Masumura M, Noda M
Sci Rep 7 5609 (2017)
PMID: 28717188

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase zeta Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.95 KDa
Source organism: Homo sapiens
Expression system: Bombyx mori
UniProt:
  • Canonical: P23471 (Residues: 1698-2000; Coverage: 13%)
Gene names: HTPZP2, PTPRZ, PTPRZ1, PTPRZ2, PTPZ
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand 7WL 1 x 7WL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 53.776Å b: 72.306Å c: 90.796Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.21 0.297
Expression system: Bombyx mori

Quick links

Citations

8 review citations

The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis.
Xia et al. (2019)
7 more

4 mentions without citation

Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
Fujikawa et al. (2017)
3 more