› 5h0n

X-ray diffraction
2.8Å resolution

Crystal structure of HIV-1 fusion inhibitor MT-WQ-IDL bound to gp41 NHR

Released:
DOI: 10.2210/pdb5h0n/pdb
PDB entry 5h0n coloured by chain, front view.
PDB entry 5h0n coloured by chain, side view.
PDB entry 5h0n coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.
Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L
J Virol 91 (2017)
PMID: 27795416

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137981 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 46 amino acids
Theoretical weight: 5.25 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 536-581; Coverage: 6%)
Gene name: env
HIV-1 fusion inhibitor MT-WQ-IDL Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 31 amino acids
Theoretical weight: 3.93 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 55.417Å b: 79.236Å c: 70.936Å
α: 90° β: 111.24° γ: 90°
R-values:
R R work R free
0.239 0.237 0.276
Expression system: Not provided

Quick links

Citations

2 review citations

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41.
Pu et al. (2019)
1 more

3 mentions without citation

Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.
Su et al. (2017)
2 more