› 5h0w

X-ray diffraction
1.9Å resolution

Crystal structure of H88F mutated human transthyretin

Released:
DOI: 10.2210/pdb5h0w/pdb
PDB entry 5h0w coloured by chain, front view.
PDB entry 5h0w coloured by chain, side view.
PDB entry 5h0w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Stability and crystal structures of His88 mutant human transthyretins.
Yokoyama T, Hanawa Y, Obita T, Mizuguchi M
FEBS Lett 591 1862-1871 (2017)
PMID: 28563699

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 13.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 31-147; Coverage: 92%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: I222
Unit cell:
a: 41.48Å b: 62.82Å c: 85.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.236
Expression system: Escherichia coli

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Citations

1 review citation

Transthyretin Misfolding, A Fatal Structural Pathogenesis Mechanism.
Si et al. (2021)
3 other articles