› 5h3n

Solution NMR

Solution structure of human Gelsolin protein domain 1 at pH 7.3

Released:
DOI: 10.2210/pdb5h3n/pdb
PDB entry 5h3n coloured by chain, ensemble of 20 models, front view.
PDB entry 5h3n coloured by chain, ensemble of 20 models, side view.
PDB entry 5h3n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1.
Fan JS, Goh H, Ding K, Xue B, Robinson RC, Yang D
Sci Rep 7 45230 (2017)
PMID: 28349924

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gelsolin Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06396 (Residues: 55-187; Coverage: 18%)
Gene name: GSN
Sequence domains: Gelsolin repeat
Structure domains: Severin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 71%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

pH-regulated single cell migration.
Stock C. (2024)
2 other articles

1 mention without citation

Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1.
Fan et al. (2017)