› 5hfq

X-ray diffraction
1.4Å resolution

Crystal structure of the second bromodomain Q443H mutant of human BRD2

Released:
DOI: 10.2210/pdb5hfq/pdb
PDB entry 5hfq coloured by chain, front view.
PDB entry 5hfq coloured by chain, side view.
PDB entry 5hfq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Lori C, Pasquo A, Chiaraluce R, Consalvi V, Fonseca M, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 344-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 32.017Å b: 52.813Å c: 72.305Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.185
Expression system: Escherichia coli

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