› 5hgj

X-ray diffraction
1.4Å resolution

Structure of integrin alpha1beta1 and alpha2beta1 I-domains explain differential calcium-mediated ligand recognition

Released:
DOI: 10.2210/pdb5hgj/pdb
PDB entry 5hgj coloured by chain, front view.
PDB entry 5hgj coloured by chain, side view.
PDB entry 5hgj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.
Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R
Sci Rep 8 2916 (2018)
PMID: 29440721

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 195 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56199 (Residues: 170-364; Coverage: 17%)
Gene name: ITGA1
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

3 bound ligands:
Ligand CA 2 x CA
Ligand CL 1 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 37.369Å b: 95.95Å c: 53.078Å
α: 90° β: 104° γ: 90°
R-values:
R R work R free
0.179 0.178 0.205
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Vanderbilt O'Brien Kidney Center.
Pozzi et al. (2021)
7 other articles

3 mentions without citation

Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Chen et al. (2018)
2 more