› 5hhv

X-ray diffraction
2.2Å resolution

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

Released:
DOI: 10.2210/pdb5hhv/pdb
PDB entry 5hhv coloured by chain, front view.
PDB entry 5hhv coloured by chain, side view.
PDB entry 5hhv coloured by chain, top view.
Source organisms:
Primary publication:
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Liu S, Desharnais J, Sahasrabudhe PV, Jin P, Li W, Oates BD, Shanker S, Banker ME, Chrunyk BA, Song X, Feng X, Griffor M, Jimenez J, Chen G, Tumelty D, Bhat A, Bradshaw CW, Woodnutt G, Lappe RW, Thorarensen A, Qiu X, Withka JM, Wood LD
Sci Rep 6 26071 (2016)
PMID: 27184415

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230002 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Interleukin-17A Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16552 (Residues: 34-155; Coverage: 92%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17
Structure domains: Cystine-knot cytokines
CAT-2000 FAB heavy chain Chain: H
Molecule details ›
Chain: H
Length: 237 amino acids
Theoretical weight: 25.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
IL-17A peptide inhibitor Chain: I
Molecule details ›
Chain: I
Length: 16 amino acids
Theoretical weight: 1.85 KDa
Source organism: synthetic construct
Expression system: Not provided
CAT-2000 FAB light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.01 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P321
Unit cell:
a: 110.2Å b: 110.2Å c: 90.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.236
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens
  • Not provided

Quick links

Citations

5 review citations

IL-17 and IL-17-producing cells in protection versus pathology.
Mills KHG. (2023)
4 more

3 mentions without citation

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Wheatley et al. (2021)
2 more