› 5hj2

X-ray diffraction
2.15Å resolution

Integrin alpha2beta1 I-domain

Released:
DOI: 10.2210/pdb5hj2/pdb
PDB entry 5hj2 coloured by chain, front view.
PDB entry 5hj2 coloured by chain, side view.
PDB entry 5hj2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.
Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R
Sci Rep 8 2916 (2018)
PMID: 29440721

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148025 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 197 amino acids
Theoretical weight: 21.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17301 (Residues: 170-366; Coverage: 17%)
Gene names: CD49B, ITGA2
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

5 bound ligands:
Ligand CA 5 x CA
Ligand CL 4 x CL
Ligand PEG 1 x PEG
Ligand SO4 3 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 144.066Å b: 144.066Å c: 130.004Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.234 0.284
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Vanderbilt O'Brien Kidney Center.
Pozzi et al. (2021)
6 other articles

4 mentions without citation

Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Chen et al. (2018)
3 more