› 5hlp

X-ray diffraction
2.45Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 424 amino acids
Theoretical weight: 47.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 65A 2 x 65A
2 modified residues:
Ligand PTR 2 x PTR
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P1
Unit cell:
a: 65.048Å b: 67.667Å c: 67.77Å
α: 79.67° β: 76.66° γ: 88.92°
R-values:
R R work R free
0.19 0.187 0.24
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease.
Toledo et al. (2017)
5 more

5 mentions without citation

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors.
Belal et al. (2022)
4 more