› 5hm7

X-ray diffraction
1.93Å resolution

The Intracellular domain of Butyrophilin 3A1 protein

Released:
DOI: 10.2210/pdb5hm7/pdb
PDB entry 5hm7 coloured by chain, front view.
PDB entry 5hm7 coloured by chain, side view.
PDB entry 5hm7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation.
Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B, Adams EJ
Proc Natl Acad Sci U S A 114 E7311-E7320 (2017)
PMID: 28807997

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Butyrophilin subfamily 3 member A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 244 amino acids
Theoretical weight: 28.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00481 (Residues: 272-513; Coverage: 50%)
Gene names: BTF5, BTN3A1
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand GOL 3 x GOL
Ligand BME 4 x BME
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 37.43Å b: 145.84Å c: 44.91Å
α: 90° β: 105.57° γ: 90°
R-values:
R R work R free
0.198 0.197 0.227
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies.
Sebestyen et al. (2020)
27 more

4 mentions without citation

An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells.
Herrmann et al. (2020)
3 more