› 5ho4

X-ray diffraction
1.85Å resolution

Crystal structure of hnRNPA2B1 in complex with 10-mer RNA

Released:
DOI: 10.2210/pdb5ho4/pdb
PDB entry 5ho4 coloured by chain, front view.
PDB entry 5ho4 coloured by chain, side view.
PDB entry 5ho4 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1.
Wu B, Su S, Patil DP, Liu H, Gan J, Jaffrey SR, Ma J
Nat Commun 9 420 (2018)
PMID: 29379020

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149684 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoproteins A2/B1 Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 20.53 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P22626 (Residues: 15-193; Coverage: 51%)
Gene names: HNRNPA2B1, HNRPA2B1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
RNA (5'-R(*AP*AP*GP*GP*AP*CP*UP*AP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.22 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2
Unit cell:
a: 109.604Å b: 38.959Å c: 70.442Å
α: 90° β: 116.26° γ: 90°
R-values:
R R work R free
0.185 0.183 0.22
Expression system: Not provided

Quick links

Citations

112 review citations

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.
Yang et al. (2018)
111 more

8 mentions without citation

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Thibault et al. (2021)
7 more