› 5hoc

X-ray diffraction
1.36Å resolution

p73 homo-tetramerization domain mutant II

Released:
DOI: 10.2210/pdb5hoc/pdb
PDB entry 5hoc coloured by chain, front view.
PDB entry 5hoc coloured by chain, side view.
PDB entry 5hoc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Gebel J, Luh LM, Coutandin D, Osterburg C, Löhr F, Schäfer B, Frombach AS, Sumyk M, Buchner L, Krojer T, Salah E, Mathea S, Güntert P, Knapp S, Dötsch V
Cell Death Differ 23 1930-1940 (2016)
PMID: 27716744

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127444 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein p73 Chains: A, B
Molecule details ›
Chains: A, B
Length: 50 amino acids
Theoretical weight: 6.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15350 (Residues: 351-398; Coverage: 8%)
Gene names: P73, TP73
Sequence domains: P53 tetramerisation motif
Structure domains: p53-like tetramerisation domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P42212
Unit cell:
a: 60.149Å b: 60.149Å c: 61.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.247
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM.
Engeland K. (2018)
8 more

1 mention without citation

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Gebel et al. (2016)