› 5hp0

Solution NMR

Solution Structure of TAZ2-p53AD2

Released:
DOI: 10.2210/pdb5hp0/pdb
PDB entry 5hp0 coloured by chain, ensemble of 20 models, front view.
PDB entry 5hp0 coloured by chain, ensemble of 20 models, side view.
PDB entry 5hp0 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Krois AS, Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE
Proc Natl Acad Sci U S A 113 E1853-62 (2016)
PMID: 26976603

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53; Histone lysine acetyltransferase CREBBP Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.71 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45481 (Residues: 1764-1855; Coverage: 4%)
  • Canonical: P04637 (Residues: 37-61; Coverage: 6%)
Gene names: Cbp, Crebbp, P53, TP53
Sequence domains:
Structure domains: TAZ domain

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept.
Uversky VN. (2016)
13 more

3 mentions without citation

Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
Krois et al. (2016)
2 more