› 5ht6

X-ray diffraction
2.09Å resolution

Crystal structure of the SET domain of the human MLL5 methyltransferase

Released:
DOI: 10.2210/pdb5ht6/pdb
PDB entry 5ht6 coloured by chain, front view.
PDB entry 5ht6 coloured by chain, side view.
PDB entry 5ht6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.
Mas-Y-Mas S, Barbon M, Teyssier C, Déméné H, Carvalho JE, Bird LE, Lebedev A, Fattori J, Schubert M, Dumas C, Bourguet W, le Maire A
PLoS One 11 e0165139 (2016)
PMID: 27812132

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive histone-lysine N-methyltransferase 2E Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 16.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZD2 (Residues: 323-458; Coverage: 7%)
Gene names: KMT2E, MLL5
Sequence domains: SET domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 65.9Å b: 65.9Å c: 112.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.209 0.242
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease.
Bhat et al. (2021)
10 more

12 mentions without citation

ARF family GTPases with links to cilia.
Fisher et al. (2020)
11 more