› 5hz6

X-ray diffraction
1.14Å resolution

FABP4 in complex with 6-Chloro-2-isopropyl-4-(3-isopropyl-phenyl)-quinoline-3-carboxylic acid

Released:
DOI: 10.2210/pdb5hz6/pdb
PDB entry 5hz6 coloured by chain, front view.
PDB entry 5hz6 coloured by chain, side view.
PDB entry 5hz6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Kühne H, Obst-Sander U, Kuhn B, Conte A, Ceccarelli SM, Neidhart W, Rudolph MG, Ottaviani G, Gasser R, So SS, Li S, Zhang X, Gao L, Myers M
Bioorg Med Chem Lett 26 5092-5097 (2016)
PMID: 27658368

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, adipocyte Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15090 (Residues: 4-132; Coverage: 98%)
Gene name: FABP4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand 65Y 1 x 65Y
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Unit cell:
a: 31.753Å b: 53.256Å c: 72.193Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.138 0.136 0.173
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.
Floresta et al. (2017)
2 other articles

4 mentions without citation

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers.
Gaffar et al. (2023)
3 more