› 5hzf

X-ray diffraction
1.55Å resolution

Single Chain Recombinant Globular Head of the Complement System Protein C1q in complex with magnesium

Released:
DOI: 10.2210/pdb5hzf/pdb
PDB entry 5hzf coloured by chain, front view.
PDB entry 5hzf coloured by chain, side view.
PDB entry 5hzf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.
Moreau C, Bally I, Chouquet A, Bottazzi B, Ghebrehiwet B, Gaboriaud C, Thielens N
Front Immunol 7 79 (2016)
PMID: 26973654

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C1q subcomponent subunit A; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C Chain: A
Molecule details ›
Chain: A
Length: 410 amino acids
Theoretical weight: 45.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P02745 (Residues: 110-245; Coverage: 61%)
  • Canonical: P02747 (Residues: 115-245; Coverage: 60%)
  • Canonical: P02746 (Residues: 117-253; Coverage: 61%)
Gene names: C1QA, C1QB, C1QC, C1QG
Sequence domains: C1q domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 80.996Å b: 52.911Å c: 89.894Å
α: 90° β: 115.19° γ: 90°
R-values:
R R work R free
0.17 0.169 0.186
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Apoptosis and Clearance of Apoptotic Cells.
Nagata S. (2018)
3 more

2 mentions without citation

Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.
Moreau et al. (2016)
1 more