› 5hzm

X-ray diffraction
2.02Å resolution

Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)

Released:
DOI: 10.2210/pdb5hzm/pdb
PDB entry 5hzm coloured by chain, front view.
PDB entry 5hzm coloured by chain, side view.
PDB entry 5hzm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of arginine asymmetrical dimethylation by PRMT6.
Wu H, Zheng W, Eram MS, Vhuiyan M, Dong A, Zeng H, He H, Brown P, Frankel A, Vedadi M, Luo M, Min J
Biochem J 473 3049-63 (2016)
PMID: 27480107

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein arginine N-methyltransferase 6 Chain: A
Molecule details ›
Chain: A
Length: 376 amino acids
Theoretical weight: 42.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96LA8 (Residues: 1-375; Coverage: 100%)
Gene names: HRMT1L6, PRMT6
Sequence domains: Methyltransferase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SAH 1 x SAH
Ligand UNX 10 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I41
Unit cell:
a: 94.19Å b: 94.19Å c: 109.609Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.175 0.204
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Inhibitors of Protein Methyltransferases and Demethylases.
Kaniskan et al. (2018)
4 more

5 mentions without citation

Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
Tewary et al. (2019)
4 more