› 5i0b

X-ray diffraction
3.09Å resolution

Structure of PAK4

Released:
DOI: 10.2210/pdb5i0b/pdb
PDB entry 5i0b coloured by chain, front view.
PDB entry 5i0b coloured by chain, side view.
PDB entry 5i0b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The discovery and the structural basis of an imidazo[4,5-b]pyridine-based p21-activated kinase 4 inhibitor.
Park JK, Kim S, Han YJ, Kim SH, Kang NS, Lee H, Park S
Bioorg Med Chem Lett 26 2580-3 (2016)
PMID: 27117431

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 4 Chain: A
Molecule details ›
Chain: A
Length: 296 amino acids
Theoretical weight: 33.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 300-591; Coverage: 49%)
Gene names: KIAA1142, PAK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 67U 1 x 67U
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P41212
Unit cell:
a: 62.986Å b: 62.986Å c: 187.111Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.269
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Pharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives.
Krause et al. (2017)
3 other articles

5 mentions without citation

Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents.
Li et al. (2022)
4 more