› 5i4e

X-ray diffraction
2.25Å resolution

Crystal Structure of Human Nonmuscle Myosin 2C motor domain

Released:
DOI: 10.2210/pdb5i4e/pdb
PDB entry 5i4e coloured by chain, front view.
PDB entry 5i4e coloured by chain, side view.
PDB entry 5i4e coloured by chain, top view.
Source organisms:
Primary publication:
Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
Chinthalapudi K, Heissler SM, Preller M, Sellers JR, Manstein DJ
Elife 6 (2017)
PMID: 29256864

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-actinin A; Myosin-14 Chain: A
Molecule details ›
Chain: A
Length: 980 amino acids
Theoretical weight: 111.59 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7Z406 (Residues: 47-784; Coverage: 37%)
  • Canonical: P05095 (Residues: 265-489; Coverage: 26%)
Gene names: DDB_G0268632, FP17425, KIAA2034, MYH14, abpA, actnA
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand AOV 1 x AOV
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Unit cell:
a: 81.12Å b: 125.61Å c: 153.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Alpha and beta myosin isoforms and human atrial and ventricular contraction.
Walklate et al. (2021)
2 more

5 mentions without citation

Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015.
Santos et al. (2023)
4 more