› 5i50

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-118779 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Myc proto-oncogene protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 14.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01106 (Residues: 365-454; Coverage: 20%)
Gene names: BHLHE39, MYC
Sequence domains:
Structure domains: Helix-loop-helix DNA-binding domain
DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3') Chain: C
Molecule details ›
Chain: C
Length: 22 nucleotides
Theoretical weight: 6.66 KDa
Source organism: synthetic construct
Expression system: Not provided
DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3') Chain: D
Molecule details ›
Chain: D
Length: 22 nucleotides
Theoretical weight: 6.85 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 36.538Å b: 95.545Å c: 64.944Å
α: 90° β: 105.9° γ: 90°
R-values:
R R work R free
0.229 0.226 0.279
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

20 review citations

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.
Madden et al. (2021)
19 more

9 mentions without citation

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc.
Massó-Vallés et al. (2020)
8 more