5i5k

X-ray diffraction
4.2Å resolution

Structure of complement C5 in complex with eculizumab

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-208338 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Eculizumab heavy chain (variable domain) Chains: H, X
Molecule details ›
Chains: H, X
Length: 230 amino acids
Theoretical weight: 24.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Eculizumab light chain (variable domain) Chains: L, Y
Molecule details ›
Chains: L, Y
Length: 214 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 197.704Å b: 269.321Å c: 202.824Å
α: 90° β: 98.58° γ: 90°
R-values:
R R work R free
0.206 0.204 0.244
Expression system: Homo sapiens