› 5i8n

Solution NMR

Solution Structure of human calcium-binding S100A9 (C3S) protein

Released:
DOI: 10.2210/pdb5i8n/pdb
PDB entry 5i8n coloured by chain, ensemble of 10 models, front view.
PDB entry 5i8n coloured by chain, ensemble of 10 models, side view.
PDB entry 5i8n coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Blocking the interaction between S100A9 and RAGE V domain using CHAPS molecule: A novel route to drug development against cell proliferation.
Chang CC, Khan I, Tsai KL, Li H, Yang LW, Chou RH, Yu C
Biochim Biophys Acta 1864 1558-69 (2016)
PMID: 27524699

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139141 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 13.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P06702 (Residues: 1-114; Coverage: 100%)
Gene names: CAGB, CFAG, MRP14, S100A9
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Refinement method: molecular dynamics
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

2 review citations

S100A12 in Digestive Diseases and Health: A Scoping Review.
Carvalho et al. (2020)
1 more

14 mentions without citation

Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners.
Weisz et al. (2020)
13 more