› 5id7

X-ray diffraction
2.26Å resolution

Crystal structure of human serum albumin in complex with phosphorodithioate derivative of myristoyl cyclic phosphatidic acid (cPA)

Released:
DOI: 10.2210/pdb5id7/pdb
PDB entry 5id7 coloured by chain, front view.
PDB entry 5id7 coloured by chain, side view.
PDB entry 5id7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties.
Sekula B, Ciesielska A, Rytczak P, Koziołkiewicz M, Bujacz A
Biosci Rep 36 (2016)
PMID: 27129297

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

3 bound ligands:
Ligand 6A4 6 x 6A4
Ligand PGE 3 x PGE
Ligand PEG 3 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P1
Unit cell:
a: 37.895Å b: 85.167Å c: 96.308Å
α: 105.46° β: 89.78° γ: 101.34°
R-values:
R R work R free
0.207 0.206 0.253

Quick links

Citations

1 review citation

Unraveling the versatility of human serum albumin - A comprehensive review of its biological significance and therapeutic potential.
Ashraf et al. (2023)
5 other articles

4 mentions without citation

Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics.
Gao et al. (2019)
3 more