› 5idz

X-ray diffraction
2.63Å resolution

Structure of Human Enolase 2 in complex with (S)-(1-hydroxy-2-oxopiperidin-3-yl)phosphonate

Released:
DOI: 10.2210/pdb5idz/pdb
PDB entry 5idz coloured by chain, front view.
PDB entry 5idz coloured by chain, side view.
PDB entry 5idz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Leonard PG, Muller FL

Function and Biology Details

Reaction catalysed: 
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-enolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 440 amino acids
Theoretical weight: 48.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09104 (Residues: 1-434; Coverage: 100%)
Gene name: ENO2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand 6BM 2 x 6BM
Ligand PGE 2 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 68.1Å b: 108.74Å c: 116.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.162 0.218
Expression system: Escherichia coli BL21(DE3)

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