› 5ijo

Electron Microscopy
21.4Å resolution

Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205)

Released:
DOI: 10.2210/pdb5ijo/pdb
PDB entry 5ijo coloured by chain, front view.
PDB entry 5ijo coloured by chain, side view.
PDB entry 5ijo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M
Science 352 363-5 (2016)
PMID: 27081072
Related structures: EMD-8085

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 208-mer (preferred)
PDBe Complex ID:
PDB-CPX-131103 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Nuclear pore complex protein Nup155 Chains: A, B, E, K, Q, W
Molecule details ›
Chains: A, B, E, K, Q, W
Length: 1391 amino acids
Theoretical weight: 155.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75694 (Residues: 1-1391; Coverage: 100%)
Gene names: KIAA0791, NUP155
Sequence domains: Nup133 N terminal like
Nuclear pore complex protein Nup93 Chains: C, I, O, U
Molecule details ›
Chains: C, I, O, U
Length: 819 amino acids
Theoretical weight: 93.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N1F7 (Residues: 1-819; Coverage: 100%)
Gene names: KIAA0095, NUP93
Sequence domains: Nup93/Nic96
Nuclear pore complex protein Nup205 Chains: D, P
Molecule details ›
Chains: D, P
Length: 2012 amino acids
Theoretical weight: 228.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92621 (Residues: 1-2012; Coverage: 100%)
Gene names: C7orf14, KIAA0225, NUP205
Sequence domains: Nuclear pore complex scaffold, nucleoporins 186/192/205
Nucleoporin p54 Chains: F, L, R, X
Molecule details ›
Chains: F, L, R, X
Length: 507 amino acids
Theoretical weight: 55.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z3B4 (Residues: 1-507; Coverage: 100%)
Gene name: NUP54
Sequence domains:
Nucleoporin p58/p45 Chains: G, M, S, Y
Molecule details ›
Chains: G, M, S, Y
Length: 599 amino acids
Theoretical weight: 60.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BVL2 (Residues: 1-599; Coverage: 100%)
Gene names: KIAA0410, NUP58, NUPL1
Sequence domains: Nucleoporin FG repeated region
Nuclear pore glycoprotein p62 Chains: H, N, T, Z
Molecule details ›
Chains: H, N, T, Z
Length: 522 amino acids
Theoretical weight: 53.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P37198 (Residues: 1-522; Coverage: 100%)
Gene name: NUP62
Sequence domains: Nsp1-like C-terminal region
Nucleoporin NUP188 Chains: J, V
Molecule details ›
Chains: J, V
Length: 1749 amino acids
Theoretical weight: 196.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5SRE5 (Residues: 1-1749; Coverage: 100%)
Gene names: KIAA0169, NUP188
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 21.4Å
Relevant EMDB volumes: EMD-8085
Expression system: Homo sapiens

Quick links

Citations

59 review citations

The nuclear pore complex: understanding its function through structural insight.
Beck et al. (2017)
58 more

13 mentions without citation

Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Kosinski et al. (2016)
12 more