› 5ijt

X-ray diffraction
2.15Å resolution

Human Peroxiredoxin 2 Oxidized (SS)

Released:
DOI: 10.2210/pdb5ijt/pdb
PDB entry 5ijt coloured by chain, front view.
PDB entry 5ijt coloured by chain, side view.
PDB entry 5ijt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT
J Biol Chem 293 11901-11912 (2018)
PMID: 29884768

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-2 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 198 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32119 (Residues: 1-198; Coverage: 100%)
Gene names: NKEFB, PRDX2, TDPX1
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 50.014Å b: 198.784Å c: 116.523Å
α: 90° β: 96.28° γ: 90°
R-values:
R R work R free
0.208 0.207 0.257
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Peroxiredoxins in Cancer and Response to Radiation Therapies.
Forshaw et al. (2019)
5 more

8 mentions without citation

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities.
Bolduc et al. (2021)
7 more