› 5ip4

X-ray diffraction
1.81Å resolution

X-RAY STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN

Released:
DOI: 10.2210/pdb5ip4/pdb
PDB entry 5ip4 coloured by chain, front view.
PDB entry 5ip4 coloured by chain, side view.
PDB entry 5ip4 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.
Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A
J Biol Chem 291 16292-306 (2016)
PMID: 27226599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208082 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
XA4551 NANOBODY AGAINST C-DCX Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.42 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Neuronal migration protein doublecortin Chains: D, E
Molecule details ›
Chains: D, E
Length: 91 amino acids
Theoretical weight: 10.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43602 (Residues: 170-260; Coverage: 25%)
Gene names: DBCN, DCX, LISX
Sequence domains: Doublecortin
Structure domains: Doublecortin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 89.84Å b: 86.191Å c: 73.267Å
α: 90° β: 123° γ: 90°
R-values:
R R work R free
0.197 0.194 0.246
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Khavinson et al. (2020)
3 more

6 mentions without citation

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis.
Carli et al. (2023)
5 more