› 5iqp

X-ray diffraction
2.6Å resolution

14-3-3 PROTEIN TAU ISOFORM

Released:
DOI: 10.2210/pdb5iqp/pdb
PDB entry 5iqp coloured by chain, front view.
PDB entry 5iqp coloured by chain, side view.
PDB entry 5iqp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways.
Xiao B, Smerdon SJ, Jones DH, Dodson GG, Soneji Y, Aitken A, Gamblin SJ
Nature 376 188-91 (1995)
PMID: 7603573

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150975 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
14-3-3 protein theta Chains: A, B
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 27.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27348 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAQ
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID2
Spacegroup: P212121
Unit cell:
a: 70.29Å b: 79.3Å c: 101Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.239
Expression system: Escherichia coli

Quick links

Citations

80 review citations

14-3-3 proteins: structure, function, and regulation.
Fu et al. (2000)
79 more

2 mentions without citation

14-3-3 phosphorylation inhibits 14-3-3θ's ability to regulate LRRK2 kinase activity.
Pattanayak et al. (2023)
1 more