› 5iwl

X-ray diffraction
2.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211960 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
5F9 diabody Chains: A, B
Molecule details ›
Chains: A, B
Length: 234 amino acids
Theoretical weight: 25.51 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Structure domains: Immunoglobulins
Leukocyte surface antigen CD47 Chains: C, D
Molecule details ›
Chains: C, D
Length: 114 amino acids
Theoretical weight: 12.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q08722 (Residues: 19-132; Coverage: 37%)
Gene names: CD47, MER6
Sequence domains: CD47 immunoglobulin-like domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 6 x NAG
Ligand PGE 2 x PGE
1 modified residue:
Ligand PCA 4 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3221
Unit cell:
a: 103.28Å b: 103.28Å c: 131.13Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.221 0.267
Expression system: Trichoplusia ni

Quick links

Citations

105 review citations

Small-cell lung cancer: what we know, what we need to know and the path forward.
Gazdar et al. (2017)
104 more

6 mentions without citation

Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPĪ± structure-function.
Jalil et al. (2020)
5 more