› 5iz5

X-ray diffraction
2.2Å resolution

Human GIVD cytosolic phospholipase A2

Released:
DOI: 10.2210/pdb5iz5/pdb
PDB entry 5iz5 coloured by chain, front view.
PDB entry 5iz5 coloured by chain, side view.
PDB entry 5iz5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
Wang H, Klein MG, Snell G, Lane W, Zou H, Levin I, Li K, Sang BC
J Mol Biol 428 2769-79 (2016)
PMID: 27220631

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic phospholipase A2 delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 814 amino acids
Theoretical weight: 91.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86XP0 (Residues: 2-810; Coverage: 99%)
Gene name: PLA2G4D
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 14 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P62
Unit cell:
a: 180.783Å b: 180.783Å c: 133.539Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.223 0.238
Expression system: Spodoptera frugiperda

Quick links

Citations

2 citation in other articles

Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium-Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity.
Zhai et al. (2020)
1 more

3 mentions without citation

Wen-Luo-Tong Decoction Attenuates Paclitaxel-Induced Peripheral Neuropathy by Regulating Linoleic Acid and Glycerophospholipid Metabolism Pathways.
Wu et al. (2018)
2 more