› 5izq

X-ray diffraction
3.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Folate receptor alpha Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 238 amino acids
Theoretical weight: 27.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15328 (Residues: 1-235; Coverage: 91%)
Gene names: FOLR, FOLR1
Sequence domains: Folate receptor family

Ligands and Environments

1 bound ligand:
Ligand 83A 7 x 83A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 90.793Å b: 144.982Å c: 211.252Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.257
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Progress in tumor-associated macrophage (TAM)-targeted therapeutics.
Ngambenjawong et al. (2017)
2 more

7 mentions without citation

Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Ravindra et al. (2018)
6 more