› 5j0b

X-ray diffraction
2.48Å resolution

Structure of the immune receptor CD33 in complex with 6'-sialyllactose

Released:
DOI: 10.2210/pdb5j0b/pdb
PDB entry 5j0b coloured by chain, front view.
PDB entry 5j0b coloured by chain, side view.
PDB entry 5j0b coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Dodd RB

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148858 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Myeloid cell surface antigen CD33 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 224 amino acids
Theoretical weight: 25.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20138 (Residues: 21-232; Coverage: 61%)
Gene names: CD33, SIGLEC3
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: GAL, SIA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 12 x NAG
Ligand PG0 2 x PG0
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 64.49Å b: 123.68Å c: 141.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.229 0.251
Expression system: Homo sapiens

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